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IL-27 induces STAT1 and STAT3 expression. Peripheral blood mononuclear cells were incubated with rIL-27 for 0 to 180 min and analyzed for expression of phosphorylated STAT1, STAT3, and STAT4 in T cells by intracytoplasmic staining. Histogram depicts phosphorylation of STAT1 (A), STAT3 (B), and STAT4 (C) on gated CD4+CD45RA+ T cells with cytokine (grey line) or without cytokine (black line) stimulation. Data are representative of one of 3 individuals tested.
