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Serum samples from melanoma patients were analyzed for β2 microglobulin (A), G1P2 (ISG15) (B), and neopterin (C) expression at day 1 (pretreatment), day 8, and day 29 after interferon (IFN)b-1a treatment by ELISAs. Significant increases (*P < 0.001) in β2 microglobulin, G1P2 (ISG15), and neopterin were identified at days 8 and 29. All patients received 22 × 106 international units (IU)/m2 on days 1–14 and 18 × 106 IU/m2 on days 15–29. IFN, interferon; ISG, IFN-stimulated genes.
