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Serum samples from melanoma patients were analyzed for VEGFa expression at day 1 (pretreatment), day 8, and day 29 after IFNb-1a treatment. The level of VEGFa was determined using the Luminex multi-analyte technology. A decrease in VEGFa (*P < 0.03) was identified at day 29. All patients received 22 × 106 IU/m2 on days 1–14 and 18 × 106 IU/m2 on days 15–29.
