Table 1.
Percentage of inner and outer hair cells in the Otof −/− and wild-type cochlea transfected with AAV-1/2 vector (means ± SD)
Vector/host strain | n | Base | Midbase | Apex |
---|---|---|---|---|
Inner hair cells | ||||
Syt1–eGFP/Otof | 7 | 20.3 ± 25.1c,d | 67.4 ± 27.0d,e | 71.1 ± 24.3b,c |
eGFP/WT | 6 | 20.7 ± 16.3h,i | 82.8 ± 21.2i,j | 67.5 ± 19.4h |
Syt1–eGFP/WT | 4 | 56.7 ± 24.0 | 75.9 ± 17.0 | 62.1 ± 15.5 |
Outer hair cells | ||||
Syt1–eGFP/Otof | 7 | 4.57 ± 6.9a | 14.2 ± 14.0e,k | 35.1 ± 23.0a,b |
eGFP/WT | 6 | 9.8 ± 7.7f,g | 36.0 ± 19.3f,j,k | 41.0 ± 20.0g |
Syt1–eGFP/WT | 4 | 27.1 ± 17.0 | 30.3 ± 24.7 | 42.9 ± 56.5 |
WT, Wild type.
ap = 0.02,
bp = 0.009,
cp = 0.006,
dp = 0.003,
ep = 0.001,
fp = 0.03,
gp = 0.02,
hp = 0.005,
ip = 0.003,
jp = 0.002, by repeated measures ANOVA;
kp = 0.04, by paired samples t test.