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. Author manuscript; available in PMC: 2011 Apr 28.
Published in final edited form as: J Neurochem. 2009 Oct 21;112(1):227–237. doi: 10.1111/j.1471-4159.2009.06445.x

Fig. 5.

Fig. 5

Diminished manganese-dependent Akt phosphorylation in HD striatal cells. (A) Lysates harvested from STHdhQ7/Q7 (wild-type) or STHdhQ111/Q111 (mutant) cells after 3 hours of manganese chloride exposure were analyzed by western blot for phosphorylated Akt (S473-P-Akt), total Akt and actin. Representative blots are shown. (B) Quantification of S473-P-Akt/total Akt expression in striatal cell lines. Mean values were normalized by genotype to the vehicle-only control (± SEM, n=4 independent samples). Significant differences in protein levels (* p<0.05 post-hoc t-test) between genotypes are indicated for each exposure.