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. 2011 Apr 13;31(15):5777–5781. doi: 10.1523/JNEUROSCI.6265-10.2011

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Copyright © 2011 the authors 0270-6474/11/315777-05$15.00/0

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Figure 3. — Bidirectional modulation of EPSPs by group I mGluRs. A, The group I mGluR agonist DHPG (5 μm) reversibly depressed monosynaptic EPSPs in CA1 stratum oriens interneurons. Inset, Representative sample traces before, during (gray), and after DHPG application (averages of 20 sweeps). B, DHPG evoked a delayed potentiation when paired with hyperpolarization. C, Interrupting stimulation of one pathway (open symbols) did not prevent the delayed potentiation induced by DHPG application together with hyperpolarization. D, Hyperpolarization alone had no long-lasting effect on transmission. E, DHPG paired with hyperpolarization had no effect on transmission when recording in whole-cell mode. F, The selective mGluR5 agonist CHPG (500 μm) induced a potentiation when paired with hyperpolarization (perforated patch). Inset, Representative traces before (black) and after (gray) CHPG .