Table 2.

Summary of Evidence Base for Outpatient Treatment in Children and Adolescents With Anorexia Nervosa and Bulimia Nervosa

Treatment Type	Eating Disorder	Studies	Level of Evidence	Recommendation
Family-Based Treatments	AN	5 RCTs(Eisler et al., 2000; Le Grange et al., 1992; Lock et al., 2005; Lock et al., in press-b; Robin et al., 1999; Russell et al., 1987)	+++	A good first line treatment
	BN	2RCTs, case series	++	A reasonable treatment option
Other Family Therapies(Minuchin et al., 1978)	AN	Case series data	+	A possible treatment option
	BN	None	0	Unknown usefulness
Adolescent Focused Therapy(Lock et al., submitted-b; Robin et al., 1999)	AN	2 RCTs	++	A reasonable treatment option
	BN	None	0	Unknown usefulness
Cognitive Behavioral Therapy(Gowers et al., 2007; Lock, 2005; Schapman and Lock, 2006; Schmidt et al., 2007)	AN	1 RCT	+	A possible treatment option
	BN	1 RCT, case series	+	A possible treatment option
Antidepressants(Kotler et al., 2003)	AN	No RCT	0	Unknown usefulness
	BN	No RCT; one case series	+	A possible treatment option
Atypical Antipsychotics(Broachie et al., 2003; Hagman et al., 2009)	AN	1 RCT; case series	++	Evidence suggests no benefit
	BN	None	0	Unknown usefulness
Nutritional Advice/Counseling(Hall and Crisp, 1987; Pike et al., 2004)	AN	2 RCTs in adults, none in adolescents	+	Limited evidence suggests little specific benefit
	BN	None	0	Unknown Usefulness

⁺⁺⁺a minimum of two RCTs demonstrating differences in efficacy over another treatment or placebo

⁺⁺a minimum of one RCT demonstrating differences in efficacy over another treatment or placebo

⁺case series data

⁰no data