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. Author manuscript; available in PMC: 2012 Feb 25.
Published in final edited form as: Angew Chem Int Ed Engl. 2011 Jan 21;50(9):2041–2044. doi: 10.1002/anie.201006818

Figure 1.

Figure 1

Schematic diagrams and TEM images of DNA origami cages. A) Schematics illustrating the challenge of assembling discrete nanoparticle architectures with site selective functionalization of the spherical nanoparticle surface. B) The formation of a DNA origami cage using short staple strands (red) to direct the folding of single stranded M13 DNA (green loop). Single stranded capture strands extend in or out of the DNA cage at specific positions. C) 3D and side view of the DNA origami cage, with 41 nm × 24 nm × 21 nm outer dimensions and 10 nm × 10 nm × 21 inner dimensions. D) Zoom out TEM image of a DNA origami cage (scale bar: 50 nm). E) Zoom in TEM images of DNA origami cages, displaying two different orientations.