Receiver operating characteristic (ROC) curve analysis of methylation profiles. (A) ROC curve based on methylation class only results in a significant area under the curve (AUC) of 0.70 (95% CI, 0.63 to 0.77). (B) ROC curve including methylation classes, patient sex, age, smoking status (never, former, current), and family history of bladder cancer results in a significant AUC of 0.76 (95% CI, 0.70 to 0.82).