Table 2.
Toxicities
| Treatment-Related Toxicities by Grade (possible) |
||||
|---|---|---|---|---|
| Adverse Event | 2 | 3 | 4 | 3/4 (%) |
| ANC | 7 | 4 | 2 | 17 |
| AST/ALT | 2 | — | — | — |
| Anorexia | 6 | 1 | — | 3 |
| Bicarbonate, serum low | 1 | — | — | — |
| Constipation | — | — | — | — |
| Creatinine | 4 | — | — | — |
| Dehydration | — | — | — | — |
| Diarrhea | 6 | — | — | — |
| Distension/bloating | 1 | — | — | — |
| Dizziness | 3 | — | — | — |
| Dry mouth/salivary gland | 2 | — | — | — |
| Dry skin | 3 | — | — | — |
| Dysphagia | 1 | — | — | — |
| Dyspnea | 2 | — | — | — |
| Fatigue | 13 | 3 | — | 9 |
| Hyperglycemia | 1 | — | — | — |
| Headache | 2 | — | — | — |
| Heartburn/dyspepsia | 1 | — | — | — |
| Hemoglobin | 6 | 4 | — | 11 |
| Hemorrhage, GU (vagina) | 1 | — | — | — |
| Hot flashes/flushes | 1 | — | — | — |
| Hypertension | 1 | — | — | — |
| Hypokalemia | — | 1 | — | 3 |
| Hyponatremia | — | 1 | — | 3 |
| Hypophosphatemia | 7 | 2 | — | 6 |
| Hypotension | 3 | — | — | — |
| Infection | ||||
| With grade 3 or 4 ANC | 2 | — | — | — |
| With < grade 3 ANC | 6 | — | — | — |
| Skin (cellulitis) | — | 1 | — | 3 |
| INR | — | 2 | — | 6 |
| Leukocytes (total WBC) | 5 | 3 | 1 | 11 |
| Lymphopenia | 3 | 4 | 1 | 14 |
| Myalgia | 2 | 1 | — | 3 |
| Mucositis/stomatitis | 1 | 1 | — | 3 |
| Muscle weakness (not neurologic) | 3 | — | — | — |
| Nail changes | 1 | — | — | — |
| Nausea/vomiting | 9 | — | — | — |
| Neuropathy: sensory | 1 | — | — | — |
| Pain (not muscle or headache) | 5 | — | — | — |
| Palpitations | 1 | — | — | — |
| Platelets | 4 | 3 | 7 | 29 |
| Pneumonitis/pulmonary infiltrate | 1 | — | — | — |
| Rash/desquamation | 1 | — | — | — |
| Somnolence | 1 | — | — | — |
| Supraventricular/nodal arrhythmia | 2 | — | — | — |
| Taste alteration | 2 | — | — | — |
| Thrombosis/thrombus/embolism | — | 1 | 1 | 6 |
Abbreviations: ANC, absolute neutrophil count; GU, genitourinary; INR, international normalized ratio for coagulant response time.