Table 5.

Significant Associations Between SNPs and QOL (SF-8)

SF-8 Variable	Period	Cytokine	SNP	OR Estimate
Bodily Pain	1	IL-1RN	rs315952	0.91–0.99
General Health	2	IL-6	rs1800795	0.86–0.95
	2	IL-1B	rs1143633	0.87–0.99
	2	IL-1RN	rs315952	1.02–1.15
	2	IL-1RN	rs380092	1.00–1.13
	3	IL-10	rs3021094	1.02–1.13
	3	IL-10	rs3024493	1.01–1.11
	3	IL-6	rs2069835	0.89–0.99
	3	IL-1B	rs1143627	0.91–0.98
Mental Health	3	IL-1RN	rs315952	0.94–0.99
	3	IL-1RN	rs380092	0.94–0.99
Physical Function	1	IL-10	rs1800871	0.90–0.98
	1	IL-1B	rs1143634	1.04–1.27
	1	IL-1RN	rs4252041	1.01–1.23
	2	IL-6	rs1800795	0.86–0.95
	2	IL-1B	rs1143633	1.02–1.15
	2	IL-1RN	rs397211	1.00–1.06
	3	TNF-α	rs3093662	0.92–0.99
	3	IL-1B	rs2853550	1.00–1.08
Role Emotion	1	IL-6	rs1800795	0.91–0.99
	1	IL-6	rs2069840	1.01–1.11
Role Physical Function	1	IL-1B	rs1143634	0.83–0.99
	2	IL-1RN	rs315952	0.86–0.95
	2	IL-1RN	rs380092	0.86–0.94
	2	IL-1RN	rs4252041	1.00–1.15
	3	IL-10	rs3021094	0.88–0.97
	3	IL-1B	rs1143627	1.01–1.07
Social Function	1	IL-6	rs2069843	0.68–0.99
	1	IL-1RN	rs380092	0.93–1.00
	3	TNF-α	rs3093661	0.88–0.99
Vitality	2	IL-10	rs1878672	0.91–0.94
	2	IL-10	rs3021094	1.02–1.18
	2	IL1-RN	rs4252041	0.80–0.97
Mental Health Component Summary Score	2	TNF-α	rs1800630	0.91–0.98
Physical Health Component Summary Score	1	IL-10	rs3021094	0.91–0.99
	3	IL-10	rs3024493	0.89–0.96

SNPs indicates single nucleotide polymorphisms; QOL, quality of life; SF-8, Medical Outcomes Study Short-Form General Health Survey; Period 1, <3 years; Period 2, 3–5 years; Period 3, >5 years; OR, odds ratio; IL, interleukin; TNF-α, tumor necrosis factor-α.