Figure 2.

Autophagy regulates protein homeostasis through interaction with p62 and NBR1. A: A schematic diagram showing the domain organization of p62 and NBR1 proteins. PB1: Phox and Bem1p domain; ZZ: Zinc finger domain; TB: TRAF6-binding domain; CC: Coiled-coil domain; LIR: LC3-interacting region; UBA: Ub-associated domain; B: p62 and NBR1 are autophagy receptors that interact with both ubiquitin-positive protein aggregates through their UBA domains and target them to autophagosomes through their LIR regions with LC3 on the autophagosomal membranes, thereby promoting autophagy of ubiquitinated targets.