Table III.

Fexofenadine disposition in single-pass perfused TR⁻ rat livers. Mean ± SD (n = 3–4 per group).

	0.5 µM Fexofenadine	0.5 µM Fexofenadine without TC	0.5 µM Fexofenadine + 2 µM GF120918	0.5 µM Fexofenadine + 5 µM Bosentan
Css,out (pmol/mL) #	92.3 ± 29.4	135 ± 21	172 ± 59*	209 ± 19*
Cliver (pmol/mL)	7295 ± 786	7156 ± 1529	8159 ± 720	5561 ± 873
Cliver, unbound (pmol/mL)	1389 ± 196	1282 ± 142	1631 ± 620	1235 ± 369
Cliver, unbound / Css,out	16.2 ± 5.4	9.53± 0.46	10.8 ± 6.0	6.05 ± 2.34*
Extraction Ratio	0.82 ± 0.06	0.73 ± 0.04	0.66 ± 0.12*	0.58± 0.04*
Biliary Excretion Rate (pmol/min/g liver)	218 ± 66	136 ± 34*	55.6 ± 6.4*	142 ± 29
Cl’biliary (mL/h/g liver)	8.57 ± 2.00	6.56 ± 2.27	2.36 ± 1.12*	7.52 ± 2.78

^*p< 0.05 fexofenadine ± modulator vs. fexofenadine alone.

^#Total concentration determined based on 50–60-min collection interval. Perfusate buffer contained 5 µM taurocholate (TC), unless otherwise noted.