Table 1.
Sensitivity analysis for number needed to harm and number needed to treat for acute symptom studies for paliperidone palmitate that used an earlier initiation regimen
| Clinical outcome NNT or NNH (95% CI) | aGopal et al25 | bNasrallah et al24 | cKramer et al23 |
|---|---|---|---|
| Response | 9 (5, 64) | 8 (5, 26) | 5 (4, 12) |
| Akathisia | 78 (24, −37) | −322 (46, −21) | −87 (42, −15) |
| Tremor | −210 (29, −18) | 100 (34, −38) | −57 (65, −14) |
| Tardive dyskinesia | 252 (46, −42) | ∞ | ∞ |
| Use of anticholinergics | 33 (10, −20) | −81 (27, −13) | 12 (7, 545) |
| AIMS positive score | 22 (8, −22) | −108 (16, −11) | −37 (13, −7) |
| Weight gain | 36 (18, −299) | 28 (17, 313) | 2739 (31, −19) |
Notes:
∞ indicates confidence interval includes infinity; initial dose on days 1 and 8:
a
50, 100, 150 mg eq;
b
25, 50, 100 mg eq;
c
50, 100 mg eq.
Abbreviations: AIMS, Abnormal Involuntary Movement Scale; NNT, number needed to treat; NNH, number needed to harm; CI, confidence interval.