Table 2.

Multivariable Models for Progression-Free Survival and Overall Survival

End Point	No. of Patients	Hazard Ratio	95% CI	P
PFS
Model I: IgVH status, unmutated v mutated	78	1.9	1.1 to 3.2	.02
Model II: cytogenetics, del(17p)/ del(11q) v other	83	1.9	1.0 to 3.6	.06
OS
Model I: IgVH status, unmutated v mutated	78	2.6	1.4 to 5.1	.004
Model II: cytogenetics, del(17p)/del(11q) v other	83	2.3	1.2 to 4.4	.01

NOTE. Each of the four models was adjusted for age, sex, Rai stage (high/intermediate), log-transformed white blood cell count, log-transformed lactate dehydrogenase, and splenomegaly (yes/no). Hazard ratios greater than or less than 1 correspond to an increased or decreased risk, respectively, of an event for the first category listed for dichotomous variables.

Abbreviations: IgV_H, immunoglobulin heavy chain variable region; PFS, progression-free survival; OS, overall survival.