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Mechanisms of coordination between RB and Hippo pathways in cell cycle control. The convergence of Hippo signaling on E2F transcription that was described in recent studies is summarized. (A) A diagram of how Rbf regulates dE2F and Yki/Sd cooperation at E2F target genes in growth-arrested cells. (B) The signaling cascade from LATS to DYRK and p130–DREAM is illustrated to explain how DREAM is assembled to silence E2F target gene expression in growth-arrested cells.
