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. 2011 Mar 7;108(17):6703–6708. doi: 10.1073/pnas.1015252108

Fig. 9.

Fig. 9.

Convergent synthesis of the core 8. (A). The C5 and C6 stereogenic centers are incorporated by Brown crotylboration. (B). The C11 and C12 stereogenic centers are incorporated by Sharpless asymmetric epoxidation, followed by a regiospecific epoxide-opening with LiCu(Me)2. (C). The C16 and C17 stereogenic centers are incorporated by Katsuki asymmetric epoxidation, followed by a regiospecific epoxide-opening with Al(Me)3/MeLi. (D). Negishi cross coupling, followed by Yamaguchi lactonization. (E). Negishi cross coupling.