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Examination of the Srx–Prx axis in human lung normal and tumor cell lines. (A) Validation of Srx-related cell signaling changes in A549 cells. (B) Expression of Srx, Prxs, and MMPs in lung normal and tumor cells. *, cell line derived from cancer metastasis. (C) Knockdown of Srx or Prx IV reduces colony formation and cell invasion in H226 cells. Compared with control, #P > 0.05, **P < 0.01 (n = 6, t test). (D) A schematic model of the Srx–Prx axis in tumorigenesis and cancer progression.
