TABLE II.
Comparison of Laboratory Variables in the Two Patient Groups
| Median (25th, 75th percentiles) |
|||
|---|---|---|---|
| Laboratory test | Group 1: no splenectomy (n = 23) | Group 2: splenectomy (n = 34) | P-value |
| Hemoglobin concentration | |||
| z-Score g/dl |
−1.05 (−2.21, −0.26) 12.2 (11.4, 13.2) |
0.86 (0.12, 1.53) 14.4 (13.6, 15) |
<0.001 NA |
| WBC count | |||
| z-score × 103/mm3 |
−0.11 (−0.51, 0.51) 7.0 (6.3, 8.4) |
1.23 (0.50, 1.83) 9.8 (8.1, 11.1) |
<0.001 NA |
| Platelet count | |||
| z-score × 103/mm3 |
−1.10 (−1.53, −0.26) 240 (193, 276) |
2.49 (1.69, 5.53) 456 (381, 525) |
<0.001 NA |
| Total cholesterol | |||
| z-score mg/dl |
−1.75 (−2.22, −0.76) 112 (95, 138) |
−0.59 (−1.28, −0.06) 164 (142, 197) |
0.001 NA |
| LDL cholesterol | |||
| z-score mg/dl |
−1.03 (−1.92, −0.55) 57 (42, 87) |
−0.50 (−0.95, 0.15) 104 (83, 128) |
0.042 NA |
| HDL cholesterol | |||
| z-score mg/dl |
−0.68 (−1.28, −0.09) 40 (36, 45) |
−0.48 (−0.79, −0.13) 43 (38, 47) |
0.162 NA |
| Triglycerides | |||
| z-score mg/dl |
−0.12 (−0.25, 0.12) 80 (65, 95) |
−0.36 (−0.49, 0.28) 83 (55, 127) |
0.680 NA |
| Total serum bilirubin (mg/dl) | 2.00 (1.50, 2.90) | 0.75 (0.50, 0.90) | <0.001 |
| Reticulocyte count (%) | 6.10 (4.70, 8.50) | 1.90 (1.40, 2.65) | <0.001 |
| Fibrinogen (mg/dl) | 273 (228, 312) | 335 (276, 370) | 0.002 |
| Homocysteinea (μ mol/L) | 6.0 (4.3, 7.8) | 9.0 (7.0, 11.0) | 0.004 |
| Lipoprotein(a)a (mg/dl) | 5.0 (2.0, 45.0) | 22.0 (4.0, 55.0) | 0.343 |
| C-reactive protein (mg/dl) | 1.18 (0.25, 3.90) | 1.61 (0.70, 3.35) | 0.757 |
Variables expressed as z-score and absolute value where appropriate.
a
n = 16 in Group 1 and n = 22 in Group 2.