Table 2.

Results of the combined analysis of the ADGC and GERAD+ consortia.

SNP	Closest Gene	CHR	MAF	Linkage Disequilibrium with the top ADGC SNP at each loci		GERAD+ Consortia *					GERAD+ & ADGC Metaanalysis
				r2	D’	Cases	Controls	P	OR	95% CI	P	OR	95% CI
rs9349407†	CD2AP	6	0.29	N/A	N/A	6283	7165	8.0×10−4	1.11	1.04-1.18	8.6×10−9	1.11	1.07-1.15
rs9296559‡	CD2AP	6	0.29	0.71	0.95	6283	7165	1.5×10−3	1.10	1.04-1.17	NA	NA	NA
rs11767557	EPHA1	7	0.21	N/A	N/A	6283	12935	3.4×10−4	0.90	0.85-0.95	6.0×10−10	0.90	0.86-0.93
rs2588969†	ARID5B	10	0.40	N/A	N/A	6283	7165	3.3×10−2	1.06‡	1.01-1.13	3.6 × 10−1	0.99	0.95-1.02
rs4948288	ARID5B	10	0.26	0.55	0.78	6992	13472	3.6×10−3	1.07‡	1.03-1.15	NA	NA	NA
rs3865444§	CD33	19	0.31	N/A	N/A	6283	7165	2.2×10−4	0.89	0.84-0.95	1.6 × 10−9	0.91	0.88-0.93

CHR=Chromosome, MAF=Minor Allele Frequency in cases and controls.

^*GERAD1, EADI1, deCODE, AD-IG.

^†results generated from imputed data. The results from the top genotyped SNP are also shown. See Supplementary Table 6 for full details.

^‡opposite direction of effect to that reported by Naj et al.

^§data imputed in the deCODE dataset.