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. 2011 Apr 28;6(4):e19146. doi: 10.1371/journal.pone.0019146

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Walker et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Data presented are mean ± SEM of total cholesterol for individuals according to the number of SNPs for which risk alleles were present. Each SNP in the FFAR1 region which was examined (rs2301151; rs1573611; rs16970264) was scored 0 or 1 based on the presence of risk alleles (dominant model). The number of SNPs with risk alleles was summed. All individuals had at least 1 SNP with risk alleles present. There was a cumulative effect on total cholesterol of 0.18±0.08 mmol/L per SNP, P = 0.03 assessed by linear regression analysis with age, gender and BMI. This was not statistically significant when accounting for multiple comparisons by the Benjamini and Hochberg False Discovery Rate procedure with q* = 0.05.