Table 1. Characteristics of the study cohort by genotype for three SNPs of FFAR1.
rs2301151 | rs1573611 | rs16970264 | ||||||||||
SNP Type/location | Non-synonymous | Near gene 3′ | Near gene 5′ | |||||||||
AA | AG | GG | P | CC | TC | TT | P | AA | GA | GG | P | |
n | 233 | 156 | 16 | 247 | 138 | 20 | 3 | 47 | 350 | |||
Genotype frequency | 0.58 | 0.38 | 0.04 | 0.61 | 0.34 | 0.05 | 0.01 | 0.12 | 0.87 | |||
Minor allele F | 0.23 | 0.22 | 0.07 | |||||||||
Age | 52.4 (9.6) | 54.4 (10.3) | 52.4 (11.2) | 0.16 | 53.6 (10.2) | 52.6 (9.5) | 54.4 (10.4) | 0.56 | 56.7 (5.13) | 54.4 (8.9) | 53.0 (10.1) | 0.56 |
Gender (M%/F%) | 43/57 | 42/58 | 19/81 | 0.16 | 40/60 | 44/56 | 50/50 | 0.89 | 67/33 | 40/60 | 41/59 | 0.91 |
MS score | 6 [5,7] | 6 [5,8] | 6 [5,8] | 0.26 | 6 [5,8] | 6 [5,8] | 6 [4,6.5] | 0.42 | 7 [6,8] | 7 [5,8] | 6 [5,7] | 0.09 |
CVD score | 2 [1,4] | 2 [1,5] | 1 [1,3] | 0.35 | 2 [1,5] | 2 [1,4] | 4 [1,7] | 0.43 | 2 [1,9] | 2 [1,5] | 2 [1,4] | 0.83 |
The data are presented as mean (SD) for age, proportion (%) for gender and median [IQR] for metabolic syndrome (MS) and cardiovascular disease (CVD) risk score for each genotype of the three SNPs of FFAR1 which were investigated. Differences (P) in characteristics between genotypes are indicated. The MS and CVD risk score were study specific see Jebb et al. [9]. SNP location data from the NCBI-SNP database.