Table 2. BMI, waist circumference and body fat by genotype for three SNPs of FFAR1.
rs2301151 | rs1573611 | rs16970264 | |||||||||||||
Difference | P | Difference | P | Difference | P | ||||||||||
AA | AG | GG | TT | TC | CC | AA | AG | GG | |||||||
BMI (kg/m2) | |||||||||||||||
mean | 28.71 | 29.41 | 30.01 | 0.67 | 0.11 | 25.61 | 28.86 | 29.31 | 1.06 | 0.009 | 28.53 | 29.53 | 28.85 | 0.55 | 0.41 |
SE | 0.32 | 0.35 | 1.67 | 0.85 | 0.41 | 0.31 | 2.25 | 0.60 | 0.26 | ||||||
n | 233 | 156 | 16 | 20 | 138 | 247 | 3 | 47 | 350 | ||||||
Waist circumference (cm) | |||||||||||||||
mean | 98.60 | 98.57 | 98.09 | 0.27 | 0.79 | 93.53 | 98.89 | 98.53 | 1.29 | 0.19 | 100.23 | 100.57 | 97.95 | 2.09 | 0.20 |
SE | 0.85 | 0.95 | 2.72 | 3.02 | 1.09 | 0.76 | 4.41 | 1.68 | 0.66 | ||||||
n | 233 | 156 | 16 | 20 | 138 | 247 | 3 | 47 | 350 | ||||||
Body fat (%) | |||||||||||||||
mean | 33.19 | 34.77 | 37.34 | 1.11 | 0.03 | 28.05 | 33.30 | 34.68 | 1.53 | 0.002 | 28.50 | 35.02 | 33.88 | −0.58 | 0.48 |
SE | 0.56 | 0.69 | 1.99 | 1.52 | 0.71 | 0.55 | 3.70 | 1.31 | 0.46 | ||||||
n | 228 | 155 | 16 | 20 | 136 | 244 | 3 | 47 | 345 |
Data are presented as mean, SEM, n stratified by genotype for each of the three SNPs. For each genotype the risk allele was defined as the BMI-increasing allele and the data are presented as the additive model. The differences in trait by genotype were assessed by linear regression analysis coding the number of risk alleles as 0,1,2. The P-value for the regression is presented and is in bold when reaching significance by the FDR-controlling procedure q* = 0.05. The recessive and dominant models defined according to the risk allele are shown in Supplementary Table S1.