Table 4. Fasting plasma lipids by genotype for three SNPs of FFAR1.
| rs2301151 | rs1573611 | rs16970264 | |||||||||||||
| Difference | P | Difference | P | Difference | P | ||||||||||
| AA | GA | GG | TT | TC | CC | AA | GA | GG | |||||||
| Total Cholesterol (mmol/L) | |||||||||||||||
| mean | 5.57 | 5.77 | 6.14 | 0.2 | 0.01 | 5.62 | 5.59 | 5.71 | 0.08 | 0.33 | 5.67 | 5.39 | 5.72 | 0.3 | 0.02 |
| SE | 0.06 | 0.07 | 0.25 | 0.20 | 0.01 | 0.06 | 0.68 | 0.14 | 0.05 | ||||||
| n | 233 | 155 | 16 | 20 | 137 | 247 | 3 | 47 | 349 | ||||||
| LDL Cholesterol (mmol/L) | |||||||||||||||
| mean | 3.51 | 3.62 | 3.9 | 0.13 | 0.09 | 3.59 | 3.5 | 3.6 | 0.05 | 0.50 | 4.02 | 3.31 | 3.61 | 0.23 | 0.05 |
| SE | 0.06 | 0.07 | 0.22 | 0.19 | 0.08 | 0.05 | 0.63 | 0.13 | 0.05 | ||||||
| n | 233 | 155 | 16 | 20 | 138 | 247 | 3 | 47 | 350 | ||||||
| HDL Cholesterol (mmol/L) | |||||||||||||||
| mean | 1.41 | 1.44 | 1.60 | 0.04 | 0.16 | 1.40 | 1.40 | 1.45 | 0.04 | 0.17 | 1.15 | 1.36 | 1.44 | 0.09 | 0.05 |
| SE | 0.02 | 0.03 | 0.08 | 0.08 | 0.03 | 0.02 | 0.10 | 0.05 | 0.02 | ||||||
| n | 233 | 155 | 16 | 20 | 137 | 247 | 3 | 47 | 349 | ||||||
| Triglycerides (mmol/L) | |||||||||||||||
| Geometric mean | 1.27 | 1.35 | 1.34 | 1.04 | 0.35 | 1.23 | 1.32 | 1.30 | 0.99 | 0.75 | 1.10 | 1.42 | 1.29 | 0.95 | 0.49 |
| 95% CI | [1.20, 1.36] | [1.25, 1.46] | [1.13, 1.59] | [0.98, 1.55] | [1.23, 1.43] | [1.22, 1.39 | [0.71, 1.69] | [1.21, 1.67] | [1.22, 1.35] | ||||||
| n | 233 | 154 | 16 | 20 | 137 | 246 | 3 | 46 | 349 | ||||||
| Non-esterified fatty acids (µmol/L) | |||||||||||||||
| Geometric mean | 651 | 650 | 522 | 0.94 | 0.04 | 630 | 648 | 646 | 0.99 | 0.63 | 603 | 635 | 650 | 1.04 | 0.5 |
| 95% CI | [622, 681] | [610, 693] | [397, 689] | [528, 752] | [611, 687] | [614, 679] | [151, 2403] | [563, 716] | [624, 676] | ||||||
| n | 226 | 149 | 16 | 20 | 132 | 240 | 3 | 46 | 337 | ||||||
| Total: HDL cholesterol ratio | |||||||||||||||
| mean | 4.14 | 4.25 | 3.98 | 0.05 | 0.60 | 4.22 | 4.24 | 4.15 | −0.08 | 0.36 | 4.94 | 4.14 | 4.17 | −0.02 | 0.91 |
| SE | 0.07 | 0.09 | 0.23 | 0.23 | 0.10 | 0.07 | 0.41 | 0.16 | 0.06 | ||||||
| n | 233 | 155 | 16 | 20 | 137 | 247 | 3 | 47 | 349 | ||||||
Data are presented as mean, SEM, n (Total, LDL, HDL and total: HDL cholesterol) or geometric mean, 95% confidence intervals, n (triglycerides, non-esterified fatty acids) stratified by genotype for each of the three SNPs. For each genotype the risk allele was defined as the BMI-increasing allele except for rs16970264 where the risk allele was defined according to the total-cholesterol increasing effect and the data are presented as the additive model. The differences in trait by genotype were assessed by linear regression analysis coding the number of risk alleles as 0,1,2. Data for plasma NEFA and triglycerides were logged for regression analysis. The beta-coefficient from the regression was exponentiated which approximates to the percentage difference. The P-value for the regression is presented. No associations reached statistical significance by the FDR-controlling procedure q* = 0.05. The recessive and dominant models, defined according to the risk allele are presented in Supplementary Table S3.