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. 2011 Apr 6;6:683–692. doi: 10.2147/IJN.S17386

Table 1.

Variables and their levels in the Box-Behnken design

Levels
–1 0 1
Independent variables
X1 = Amount of lipid (w/v) 5% 7.5% 10%
X2 = Amount of surfactant (w/v) 2% 5% 8%
X3 = Drug/lipid ratio (w/w) 5% 10% 15%
Dependent variables Constraints
Y1 = Entrapment efficiency (EE%) Maximize
Y2 = Drug loading (DL%) Maximize
Y3 = Turbidity (NTU) Minimize