Table 1. Baseline characteristics of study subjects by mismatch repair mutation status.
| Carriers | Noncarriers | |||
|---|---|---|---|---|
| Endometrial cancer | No endometrial cancer | Endometrial cancer | No endometrial cancer | |
| N (%) | N (%) | N (%) | N (%) | |
| Total number | 126 | 475 | 8 | 525 |
| Age (year),* mean (SD) | 47.6 (8.2) | 42.2 (12.1) | 44.5 (9.9) | 48.2 (15.4) |
| MMR gene mutated | ||||
| MLH1 | 42 (33) | 203 (43) | ||
| MSH2 | 68 (54) | 231 (49) | ||
| MSH6 | 14 (11) | 24 (5) | ||
| PMS2 | 2 (2) | 17 (3) | ||
| Study Centers | ||||
| Australia or New Zealand | 75 (60) | 330 (69) | 4 (50) | 438 (83) |
| USA | 21 (17) | 47 (10) | 3 (38) | 60 (12) |
| Canada | 30 (23) | 98 (21) | 1 (12) | 27 (5) |
| Contraceptive Use† | ||||
| Never | 63 (53) | 151 (33) | 3 (43) | 170 (33) |
| Ever | 55 (47) | 309 (67) | 4 (57) | 344 (67) |
| Unknown | 8 | 15 | 1 | 11 |
| Year of Birth | ||||
| <1940 | 44 (35) | 87 (18) | 2 (25) | 110 (21) |
| 1940-1949 | 44 (35) | 85 (18) | 3 (38) | 102 (20) |
| 1950-1959 | 33 (26) | 117 (25) | 2 (25) | 133 (25) |
| ≥1960 | 5 (4) | 186 (39) | 1 (12) | 180 (34) |
| Cigarette Smoking‡ | ||||
| Never | 88 (72) | 256 (55) | 4 (57) | 315 (60) |
| Ever | 35 (28) | 210 (45) | 3 (53) | 206 (40) |
| Unknown | 3 | 9 | 1 | 4 |
| Age at menarche (year), mean (SD) | 12.6 (1.4) | 12.9 (1.6) | 13.3 (0.9) | 13.0 (1.6) |
| Body size, mean (SD) | ||||
| Current height (cm) | 163.1 (7.3) | 163.6 (7.2) | 164.4 (4.3) | 163.8 (7.2) |
| Weight at age 20 (kg) | 56.5 (10.9) | 58.8 (11.1) | 59.1 (5.9) | 58.5 (11.9) |
| BMI at age 20 (kg/m2)§ | 21.2 (3.4) | 21.9 (3.8) | 21.9 (2.6) | 21.8 (4.0) |
*
Age at first diagnosis of endometrial cancer for affected participants; age at hysterectomy or diagnosis of another cancer or last interview or death (whichever came first) for unaffected participants.
†
Oral contraceptive pills or other hormonal contraceptives (implants or injections) use at age 20 years for at least one year.
‡
Cigarette smoking status at age 20 years. Cigarette smoking was defined as ever smoking one cigarette per day for at least three months.
§
Calculated from self-reported current height and weight at age 20 years