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Plaque in an untreated MPS-I dog showing disruption of internal elastic lamina (black). Plaque matrix with GAG (blue-green) separating smooth muscle cells (red), containing cytoplasmic storage material (vacuolation). Smaller foamy macrophages, also with cytoplasmic GAG storage, are scattered throughout and clustered in this image (arrow) around a free end of the internal elastic lamina (Movat’s modified pentachrome).
