Table 2.

Combination index (CI) and dose reduction values for inhibition of HIV-1 infection by combining HP-OVA with RTIs ^a

Combinations of HP-OVA with RTIs (weight ratio)	CI	HP-OVA			RTIs
		Conc.(μg/ml)		Dose reduction	Conc.(μg/ml)		Dose reduction
		Alone	Mix		Alone	Mix
Inhibition of HIV-1IIIB infection
HP-OVA: Tenofovir (20:1)
50% inhibition	0.242	0.687	0.061	11.26	0.020	0.003	6.667
90% inhibition	0.270	3.914	0.237	16.51	0.057	0.012	4.750
HP-OVA: UC781 (100:1)
50% inhibition	0.536	1.312	0.484	2.711	0.029	0.005	5.800
90% inhibition	0.604	3.053	1.232	2.478	0.061	0.012	5.083
HP-OVA: TMC120 (1000:1)
50% inhibition	0.284	0.847	0.188	4.505	0.003	0.0002	15.92
90% inhibition	0.490	3.050	1.043	2.924	0.007	0.001	6.836
Inhibition of HIV-1BaL infection
HP-OVA: Tenofovir (1000:1)
50% inhibition	0.162	4.854	0.320	15.17	0.017	0.002	8.500
90% inhibition	0.343	22.09	1.900	11.63	0.037	0.010	3.700
HP-OVA: UC781 (1250:1)
50% inhibition	0.363	4.854	1.349	3.598	0.013	0.001	13.00
90% inhibition	0.300	22.09	4.354	5.073	0.034	0.003	11.33
HP-OVA: TMC120 (8000:1)
50% inhibition	0.173	4.854	0.413	11.75	0.001	0.00008	12.64
90% inhibition	0.124	22.09	0.952	23.20	0.002	0.0002	11.32

^aData are the means of two independent experiments performed in triplicate.