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. Author manuscript; available in PMC: 2011 Oct 28.
Published in final edited form as: Nature. 2011 Apr 3;472(7344):466–470. doi: 10.1038/nature09817

Figure 4.

Figure 4

Mice with more adult-born neurons display increased exploratory behaviour and decreased anxiety-like behaviour in the open field test following a voluntary exercise regimen. a, Experimental design. Mice were transferred to cages with running wheels five weeks following Veh/TAM treatment. b, Representative images of Dcx and BrdU (red)/NeuN (green) immunostained coronal hippocampal sections of Veh and TAM treated NCff mice. Quantification of Dcx population. Total Dcx+ neurons: 14527 ± 987 (NCff+Veh), 19893 ± 2022 (NCff+TAM), P=0.05. Number of BrdU+ cells in the GCL: 2119 ± 204 (NCff+Veh), 9324 ± 463 (NCff+TAM), ** P<0.0001. n=4–5 mice per group. c, NCff+TAM mice show significantly greater locomotor activity, reduced anxiety-like behaviour and a significant increase in rearing events in the Open Field test compared to NCff+Veh mice. n=10 (Veh) and n=11 (TAM) mice. *P<0.05, **P<0.01. Results are mean ± SEM. Scale bar 100μm.