Table 2.

Clinicopathological variables of serum matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 in patients

Variables	MMP-1	TIMP-1	P
Lymphovascular invasion
Negative	543 (500-678)	489 (450-573)
Positive	801 (768-845)	642 (567-703)	< 0.001
Tumor size (cm)
< 4	478 (460-501)	429 (425-479)
≥ 4	675 (509-725)	671 (532-690)	< 0.001
Lymph node metastasis
Negative	563 (503-650)	642 (598-709)
Positive	742 (657-799)	756 (570-876)	< 0.001
T stage
T0-2	521 (498-599)	598 (564-783)
T3-4	674 (578-783)	749 (570-794)	< 0.001
TNM stage
I	469 (458-502)	476 (423-512)
II	534 (467-563)	521 (478-589)
III	714 (546-857)	753 (512-699)	< 0.001
IV	765 (699-900)	975 (812-1134)	< 0.001

MMP-1: Matrix metalloproteinase-1; TIMP-1: Tissue inhibitor of metalloproteinase-1.