Table 1.
Mean changes in weight, fitness, and CVD risk factors in Intensive Lifestyle Intervention (ILI) and Diabetes Support and Education (DSE) and the difference between the two groups averaged over the four years
| Measure | Mean Change DSE | Mean Change ILI | Mean Difference ILI -DSE |
p-Value |
|---|---|---|---|---|
| Weight (% initial weight) | −0.88 (−1.12, −0.64) | −6.15 (−6.39, −5.91) | −5.27 | <0.0001 |
| Fitness (% METS) | 1.96 (1.07,2.85) | 12.74 (11.87, 13.62) | 10.78 | <0.0001 |
| HbA1c1 | −0.09 (−0.13, −0.06) | −0.36 (−0.40, −0.33) | −0.27 | <0.0001 |
| SBP (mmHg)1 | −2.97 (−3.44, −2.49) | −5.33 (−5.80, −4.86) | −2.36 | <0.0001 |
| DBP (mmHg)1 | −2.48 (−2.73, −2.24) | −2.92 (−3.16, −2.68) | −0.43 | 0.012 |
| HDL Cholesterol (mg/dl)1 | 1.97 (1.73, 2.22) | 3.67 (3.43, 3.91) | +1.70 | <0.0001 |
| Triglyceride (mg/dl)1 | −19.75 (−22.11, −17.39) | −25.56 (−27.91, −23.21) | −5.81 | 0.0006 |
| LDL Cholesterol (mg/dl) | −12.84 (−13.67, −12.00) | −11.27 (−12.10, 10.44) | +1.57 | 0.009 |
| LDL Cholesterol (adjusting for medication use) (mg/dl) | −9.22 (−10.04, −8.39) | −8.75 (−9.56, −7.94) | +0.47 | 0.42 |
1
Data presented are average effects unadjusted for medication use.
Adjusting for baseline use of medications or changes over time did not influence the average effect or the p-value. For LDL-cholesterol, the data are presented with and without medication adjustments.