Table 2.

Structure used to refine the questions into indicative uncertainties

Type of question	Format of question
Effectiveness of a single treatment	How effective is [treatment X] in treating vitiligo?
One treatment compared with another	Which treatment is more effective in treating vitiligo: [treatment X or treatment Y]?
One treatment combined with another	How effective is [treatment X] when combined with [treatment Y] in treating vitiligo?
Management of the disease, rather than ‘treatment’ (e.g. camouflage or psychological interventions)	How much does [treatment X] help patients with vitiligo?
Speculative treatments not yet on the market (e.g. gene therapy, stem cell therapy)	What role might [treatment X] play in the treatment of vitiligo?