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Bidirectional transport of 25 and 100 µM ciprofloxacin in MDCKI and MDCKI-MDR1 cells
| Papp × 10−7 (avg ± SD, n = 3, cm/s) | B→A | |||
|---|---|---|---|---|
| Cell Line | Concentration | B→A | A→B | A→B |
| MDCKI | 25 | 4.5 (0.4) | 10.6 (1.2) | 0.4 |
| MDCKI | 100 | 3.8 (0.4) | 9.2 (0.9) | 0.4 |
| MDCKI 4°C | 25 | 2.1 (0.7) | 1.7 (0.4) | 1.2 |
| MDCKI-MDR1 | 25 | 35.4 (1.0) | 3.5 (0.4) | 10 |
| MDCKI-MDR1 | 100 | 21.9 (1.4) | 1.0 (0.03) | 22 |
| MDCKI-MDR1 4°C | 25 | 1.3 (0.4) | 1.1 (0.2) | 1.2 |
| No cells | 25 | 128.3 (2.8 | 153.7 (30.9) | 0.8 |
