Table 3.
Hydrocortisone permeability coefficient and the R2 for linear fitting of all formulations diffusing through non-prewashed mouse skin
| Formulation | n | Permeability coefficient(cm/hr) | R2 |
|---|---|---|---|
| Corticool gel* | 3 | 8.572 * 10−3 | 0.998 |
| Cortizone-10 plus cream† | 4 | 2.366 * 10−3 | 0.862 |
| Cortaid cream† | 5 | 2.138 * 10−3 | 0.961 |
| Cortaid lotion† | 3 | 1.326 * 10−3 | 0.987 |
| Cortizone-10 ointment* | 3 | 2.419 * 10−5 | 0.904 |
| Aveeno cream† | 6 | 1.026 * 103 | 0.952 |
| Prescription HC 2.5%† | 6 | 1.264 * 10−3 | 0.916 |
*
The permeability with solubility 1 mg/mL.
†
The permeability with solubility 0.28 mg/mL.