Table 3.
Effect of α-, β1-, or β3-adrenergic receptor antagonists on intestinal OEA levels (pmol/g)
| α-Adrenergic antagonist |
β1-Adrenergic antagonist |
β3-Adrenergic antagonist |
||||
|---|---|---|---|---|---|---|
| V | Prazosin | V | CGP2071 | V | SR59230 | |
| FD | 68.1 ± 7.4 | 55.4 ± 5.4 | 58.2 ± 8.3 | 67.1 ± 3.5 | 90.3 ± 9.5 | 114.2 ± 8.9 |
| RF | 172.1 ± 25 | 123.5 ± 21.7 | 155.5 ± 21.7 | 108 ± 9.4 | 186.5 ± 23.6 | 172.3 ± 23.8 |
Administration of α-, β1-, or β3-adrenergic receptor antagonists does not affect jejunal OEA levels in refed rats. Thirty minutes of refeeding (RF) after 24 h of food deprivation in vehicle (V)-treated animals increased jejunal OEA levels compared to 24 h food deprivation alone (FD). Systemic treatment with α- (prazosin), β1- (CGP2071), or β3- (SR59230A) adrenergic receptor antagonists did not alter OEA mobilization. Results are expressed as mean ± SEM; n = 6/condition.