Figure 1a. The comparison of collagen of experimental data (the average value of samples during a 28-day period, unit: up/cm2) with a simulated data from the mathematical model.
Figure 1b. The original Dale model (blue) has asymptotic collagen variable goes to increase linearly as time increases. The proposed foreign body reaction model incorporated macrophage cell using physiological principal and Mass-action law, and improved model (red) is shown to have realistic behavior.
Figure 1. (c) The total collagen level for up to 40 days at different levels of A6. (d) The total collagen level for up to 40 days at different levels of B24. The normal level is the parameter used in current model.