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A. Conceptual hypothesis of hypoxia-induced degradation of MLC2. During oxidative stress, such as hypoxia, there is an increase in production of peroxynitrite (ONOO−) leading to modification of MLC2 within the sarcomere of a cardiac myocyte. The modified MLC2 becomes a substrate for MMP-2, and its subsequent degradation leads to the development of cardiac systolic dysfunction.
