Table 3. Shared association signals between UC and CD.
A shared association is defined as a confirmed association (Pcombined < 5×10-8) in either UC or CD and Pmeta < 1×10-4 in the other form of IBD. For more details and comparative results across all 99 reported IBD risk loci see Supplementary table 9.
| LOCUS | GENE | INDEX SNP | CD-META (6333/15056) | UC-META (6687/19718) | |||||
|---|---|---|---|---|---|---|---|---|---|
| Chr. | Left-Right (Mb) | Candidate | SNP | Risk Allele | Allele frequency in controls | p-value | OR (95% CI) | p-value | OR (95% CI) |
| 1p31 | 67.30-67.54 | IL23R | rs11209026 | G | 0.94 | 1.00×10-64 | 2.67 (2.37-3.01) | 5.12×10-28 | 1.74 (1.57-1.92) |
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| 1q32 | 199.0 -199.33 | KIF21B | rs7554511 | C | 0.72 | 1.58×10-7 | 1.14 (1.08-1.19) | 2.04×10-13 | 1.19 (1.14-1.25) |
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| 1q32 | 204.85-205.11 | IL10 | rs3024505 | A | 0.16 | 8.32×10-9 | 1.18 (1.12-1.25) | 5.76×10-17 | 1.25 (1.19-1.32) |
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| 2p16 | 60.76-61.87 | REL | rs7608910 | G | 0.39 | 3.11×10-7 | 1.14 (1.09-1.21) | 1.70×10-14 | 1.19 (1.14-1.24) |
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| 2q11 | 101.66-102.13 | IL1R2 | rs2310173 | T | 0.46 | 8.31×10-5 | 1.09 (1.04-1.14) | 8.44×10-8 | 1.12 (1.07-1.16) |
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| 3p21 | 48.14-51.77 | MST1 | rs3197999 | A | 0.30 | 6.17×10-17 | 1.22 (1.16-1.27) | 1.86×10-17 | 1.21 (1.16-1.26) |
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| 5p13 | 40.32-40.85 | PTGER4 | rs6451493 | T | 0.61 | 1.61×10-27 | 1.35 (1.28-1.43) | 1.78×10-6 | 1.12 (1.07-1.17) |
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| |||||||||
| IL12B | rs6871626 | A | 0.33 | 6.08×10-12 | 1.15 (1.10-1.20) | 1.02×10-8 | 1.12 (1.08-1.17) | ||
| 5q33 | 158.46-158.86 | IL12B | rs6556412 (r2=0.03) | A | 0.34 | 5.37×10-14 | 1.18 (1.13-1.23) | 1.69×10-5 | 1.09 (1.05-1.14) |
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| 6p22 | 20.60-21.25 | CDKAL1 | rs6908425 | C | 0.78 | 1.41×10-8 | 1.17 (1.11-1.23) | 7.75×10-5 | 1.11 (1.05-1.16) |
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| 6q21 | 106.51-106.67 | PRDM1 | rs6911490 | T | 0.21 | 4.28×10-7 | 1.12 (1.07-1.18) | 3.51×10-7 | 1.13 (1.07-1.18) |
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| 9p24 | 4.93-5.29 | JAK2 | rs10758669 | C | 0.35 | 1.00×10-13 | 1.18 (1.13-1.23) | 8.52×10-13 | 1.16 (1.11-1.21) |
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| 9q32 | 116.48-116.74 | TNFSF15 | rs4246905 | C | 0.71 | 1.33×10-15 | 1.21 (1.15-1.28) | 4.77×10-8 | 1.13 (1.08-1.18) |
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| 9q34 | 138.27-138.55 | CARD9 | rs10781499 | A | 0.40 | 3.49×10-18 | 1.20 (1.15-1.26) | 6.95×10-13 | 1.16 (1.11-1.21) |
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| 10p11 | 35.22-35.94 | CREM/CCNY | rs12261843 | G | 0.29 | 1.87×10-9 | 1.15 (1.10-1.20) | 2.35×10-8 | 1.13 (1.08-1.18) |
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| 10q21 | 63.97-64.43 | ZNF365 | rs10761659 | G | 0.54 | 4.37×10-22 | 1.23 (1.18-1.28) | 7.39×10-6 | 1.10 (1.05-1.14) |
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| 10q24 | 101.25-101.33 | NKX2.3 | rs6584283 | T | 0.47 | 7.18×10-20 | 1.21 (1.16-1.27) | 8.46×10-21 | 1.21 (1.16-1.26) |
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| 11q13 | 75.72-76.02 | C11Orf30 | rs2155219 | T | 0.50 | 1.58×10-12 | 1.16 (1.11-1.21) | 6.33×10-8 | 1.12 (1.07-1.16) |
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| 15q22 | 65.2-65.27 | SMAD3 | rs17293632 | T | 0.24 | 1.41×10-13 | 1.19 (1.14-1.25) | 9.52×10-6 | 1.11 (1.06-1.16) |
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| 17q12 | 34.62-35.51 | ORMDL3 | rs2872507 | A | 0.46 | 1.51×10-9 | 1.14 (1.09-1.19) | 5.44×10-11 | 1.15 (1.10-1.19) |
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| 18p11 | 12.73-12.92 | PTPN2 | rs1893217 | G | 0.16 | 1.29×10-14 | 1.25 (1.18-1.32) | 4.78×10-5 | 1.12 (1.06-1.18) |
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| 19p13 | 10.26-10.5 | TYK2 | rs12720356 | C | 0.08 | 9.20×10-10 | 1.22 (1.14-1.31) | 3.90×10-6 | 1.17 (1.09-1.26) |
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| 19q13 | 38.42-38.47 | - | rs736289 | T | 0.61 | 2.69×10-7 | 1.11 (1.06-1.16) | 1.89×10-5 | 1.08 (1.03-1.12) |
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| 20q13 | 61.66-61.98 | RTEL1/SLC2A4RG | rs2297441 | A | 0.76 | 1.83×10-11 | 1.19 (1.13-1.25) | 5.78×10-8 | 1.14 (1.09-1.20) |
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| 21q21 | 15.62-15.77 | - | rs1297265 | A | 0.57 | 1.41×10-8 | 1.16 (1.10-1.22) | 1.73×10-7 | 1.11 (1.06-1.16) |
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| 21q22 | 39.34-39.41 | - | rs2836878 | G | 0.74 | 3.22×10-6 | 1.12 (1.06-1.17) | 1.86×10-22 | 1.25 (1.20-1.32) |
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| 21q22 | 44.41-44.52 | ICOSLG | rs2838519 | G | 0.39 | 2.09×10-14 | 1.18 (1.13-1.23) | 2.26×10-8 | 1.12 (1.08-1.17) |
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| 22q11 | 20.14-20.39 | YDJC | rs181359 | A | 0.19 | 6.31×10-13 | 1.21 (1.15-1.28) | 2.73×10-5 | 1.11 (1.06-1.17) |