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. 2011 May;13(5):428–438. doi: 10.1593/neo.101620

Figure 4.

Figure 4

The CaR was necessary for the rapid development of HHM in the HARA xenograft model. (A) Kaplan-Meier analysis indicated HHM developed more rapidly in HARA shRNA empty-vector mice than HARA shRNA-CaR (P = .023). (B) Average tumor volume at the time of hypercalcemia. (C) Average plasma [PTHrP] in the HARA shRNA empty-vector mice were 190% greater (23 vs 8.0 pM) compared to the HARA shRNA-CaR mice (P = .11). (D) Comparison of plasma total [Ca2+] in HARA shRNA empty-vector and HARA shRNA-CaR mice before xenografting (baseline) and at the time of HHM. No differences were observed.