Figure 7.

Xenograft models of BEN SCCs overexpressing either CaR^WT, CaR^R990G or the empty-vector. (A) Kaplan-Meier analysis indicated HHM developed more rapidly in BEN CaR^R990G than BEN CaR^WT (P < .001). (B) Tumor volume at the time of hypercalcemia (P < .05). (C) Comparison of plasma PTHrP in the mice with tumors. Mice with BEN CaR tumors were hypercalcemic, and mice expressing BEN empty-vector cells were not. Plasma PTHrP was measured before xenografting (baseline), at the time of development of HHM for the BEN CaR-bearing mice, and at the time of meeting early removal criteria for the BEN empty-vector xenografts.