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. 2011 May;13(5):445–452. doi: 10.1593/neo.101734

Figure 2.

Figure 2

(A) Selectin inhibitory activity of C-C hexasaccharides. The ability of STMCα,α and STMCα,β hexasaccharides to inhibit P-selectin-mediated adhesion of LS-180 human colon carcinoma cells was compared to that of unfractionated heparin as described in Materials and Methods. Data are representative of three independent experiments. (B) Bioavailability of STMCα,β in vivo. Platelet adhesion to intravenously injected MC-38GFP cells was analyzed in mice receiving STMCα,β and compared to PBS-injected mice. The number of tumor cells positive for platelet staining was determined in lungs from mice killed at 30 minutes, 3 hours, or 7 hours after injection as described in Materials and Methods. The difference in platelet/tumor cell association between control-injected mice (PBS) and STMCα,β-injected mice was found to be statistically significant at 30 minutes and 3 hours by one-way ANOVA (P < .001).