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. 2011 May 1;22(9):1452–1462. doi: 10.1091/mbc.E10-07-0654

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© 2011 Chang et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 3: — Aβ stimulation triggers dispersion of lamin A and lamin B1 in a Cdk5-dependent manner in HT22 cells. (A) Aβ stimulates Cdk5 kinase activity. Cdk5 was immunoprecipitated from either control (column 1) or Aβ-treated HT22 cells (for 30 min), and the kinase assay was conducted as described in Materials and Methods. C, (B and C) HT22 cells were treated with 25 μM Aβ^25–35 for 4 h, followed by immunostaining with lamin A (B, green) or lamin B1 (C, red), and DAPI (blue). Representative pictures are shown. Scale bar, 20 μm. (D) Percentage of cells showing lamin A dispersion was counted. (E) Percentage of cells showing lamin B1 dispersion was counted. Bar graphs shown are mean ± SD (*p < 0.05, ***p < 0.001).