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. 2011 May 1;22(9):1452–1462. doi: 10.1091/mbc.E10-07-0654

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© 2011 Chang et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 7: — Cdk5 induction causes the accumulation of lamins at nuclear membrane and nuclear irregularity in p25-inducible transgenic mice. After a 2-wk induction of p25, the nuclear accumulation of lamin is evident in hippocampal neurons (CA1) (B and E) compared with controls (A and D). Further accumulation of lamin and nuclear irregularity is more prominent after 4 wk of induction of p25 (C and F). Scale bar, 20 μm.