Table 6. The effect of intravenous administration with vehicle or honokiol on hematology of rats and data represented the mean ± SD (n = 5).
Parameter | Vehicle | Honokiol(20 mg/kg) | Honokiol(40 mg/kg) | Honokiol(80 mg/kg) |
WBC (109/L) | 3.64±0.71 | 3.56±0.78 | 4.03±1.11 | 3.73±1.21 |
NEU (109/L) | 0.299±0.118 | 0.342±0.213 | 0.356±0.181 | 0.371±0.180 |
LYM (109/L) | 3.32±0.61 | 3.11±0.86 | 3.55±1.02 | 3.43±1.03 |
MONO (109/L) | 0.042±0.023 | 0.039±0.023 | 0.046±0.031 | 0.048±0.029 |
EOS (109/L) | 0.032±0.011 | 0.031±0.015 | 0.034±0.015 | 0.029±0.011 |
BASO (109/L) | 0.003±0.004 | 0.003±0.001 | 0.005±0.006 | 0.005±0.003 |
NEU% (%) | 8.72±1.98 | 10.01±4.31 | 9.89±3.92 | 9.91±3.92 |
LYM% (%) | 90.1±2.7 | 88.6±5.7 | 88.5±5.6 | 88.9±5.2 |
MONO% (%) | 1.358±0.586 | 1.137±0.962 | 1.801±1.972 | 1.153±0.881 |
EOS% (%) | 0.841±0.139 | 0.851±0.314 | 0.871±0.367 | 0.724±0.286 |
BASO% (%) | 0.120±0.075 | 0.095±0.085 | 0.153±0.089 | 0.127±0.080 |
RBC (1012/L) | 6.36±0.39 | 6.61±0.38 | 6.41±0.29 | 6.28±0.22 |
HGB (g/L) | 138±9 | 131±8 | 135±6 | 128±8 |
HCT (%) | 41.2±1.3 | 41.3±1.4 | 41.2±1.5 | 40.9±1.3 |
MCV (fL) | 64.6±1.9 | 64.1±2.1 | 64.0±1.8 | 64.2±1.6 |
MCH (pg) | 20.8±0.8 | 20.8±0.7 | 20.5±0.6 | 20.7±0.7 |
MCHC (g/L) | 324±5 | 322±6 | 321±8 | 320±7 |
RET (%) | 3.56±0.91 | 3.63±0.87 | 3.43±0.92 | 3.49±0.69 |
PLT (109/L) | 1134±123 | 1143±98 | 1161±126 | 1150±172 |
PT (sec) | 8.2±0.4 | 8.1±0.5 | 8.2±0.2 | 8.2±0.2 |
APTT (sec) | 17.2±1.5 | 17.3±1.9 | 17.2±1.5 | 17.1±1.6 |