Figure 5. Myometrial 
model.
Steady-state properties of 
are derived from experimental data of myometrial longitudinal cells in late pregnant rats [17]; the kinetics are from myometrial cells in late pregnant women from Knock et al., [19] and Knock G & Aaronson P (personal communication, including unpublished time tracings - see Figure S4). A, V-dependent steady-states of activation (
) and inactivation (
). B, V-dependent activation time constants (
). C, V-dependent fast (
) and slow (
) inactivation time constants. The experimental fast (solid circles) and slow (empty circles) inactivation time constants were extracted by fitting voltage-clamp time tracings averaged from five cells (1 published and 4 unpublished with the average values labeled as ‘Knock et al 1999+unpublished (Knock & Aaronson)’ in the figure). D, simulated I–V relationship of 
from holding potentials of 
and 
with 
and 
; all values are normalized to the peak current at 
from 
. E, simulated time tracings and averaged raw data of 
at voltage steps of 
to 
from 
of 
; both simulated and experimental currents are normalized to the peak current at 
; F, enlarged E showing activation of 
during the first few hundred milli-seconds.