Figure 8. Myometrial 
model.
The calcium- (
), voltage- (V) and time-dependent kinetics for the two types of 
currents, 
and 
, are developed with experimental data from cloned mammalian myometrial and smooth muscle MaxiK 
and 
subunits expressed in Xenopus laevis oocytes [63], [64]; the current density and proportion of 
are adjusted with I–V relationships from different mammalian myometrial cells [17], [65], [66]. In A and C, solid and empty circles are experimental data for 
and 
respectively. A, 
-dependent half-activation (
) and activation gating charge. B, simulated activation steady-states for 
and 
at different 
; solid and empty circles are experimental data from Orio et al., [64] and Bao & Cox [63] respectively. C, V-dependent activation time constants for 
and 
. D, simulated I–V relationships of 
at anticipated myometrial resting and peak 
levels, with the proportion of 
. Both I–V relationships are normalized to 
at 
at peak 
level.