Figure 6. Cell migration in angled competing gradients.

(A) Cells expressing desensitizable receptors migrate toward the nearer ligand source in angled competing gradients of two identical ligands; (B) In angled competing gradients of ligand L₁ and L₂, cells expressing desensitizable receptors migrate toward the mid-point between the ligand sources of L₁ and L₂. The inserted figures in (A, B) are previous neutrophil migration studies in under agarose assays [13] (Reproduced from Reference 13 with the permission from The Journal of Cell Biology for noncommercial third-party use.). (C) In contrast to (A), cells expressing nondesensitizable receptors migrate toward the mid-point between the two ligand sources of two identical ligands. (D) In contrast to (B), cells expressing nondesensitizable receptors migrate toward the nearer ligand sources. (E) Cells expressing nondesensitizable receptors to L₁ but desensitizable receptors to L₂, migrate toward nondesensitizing ligand source L₁. The total time of simulated cell migration is 75 minutes. Nine representative cell tracks are shown, and the starting positions of the tracks are consistent in all simulations. The end of the tracks is indicated by solid circles.