Skip to main content
. 2011 Apr 29;6(4):e18920. doi: 10.1371/journal.pone.0018920

Figure 10. Summary of importin binding by the N-terminal KSHV LANA NLS.

Figure 10

Residues conserved between KSHV and RFHVMn LANA within the N-terminal chromatin binding motif (CBM) and the classical bipartite Lys/Arg-rich kr-NLS are indicated above the line. Residues considered to be important within the extended non-classical Arg/Gly-rich rgNLS, including the conserved glutamine are shown below the line. The RanGTP-insensitive binding of the bipartite KSHV kr-NLS to the minor and major NLS binding sites within importin α is depicted. The RanGTP-sensitive binding of the IBB domain of importin α to the C-terminal HEAT repeats of importin β1, a critical step in the importin α/β-mediated classical nuclear import pathway (see text), is shown. The direct, RanGTP-sensitive binding of the N-terminal HEAT repeats of importin β1 to the non-classical rg-NLS of KSHV LANA, a critical step in the importin α-independent non-classical nuclear import pathway mediated by importin β1 is also depicted (see text).