Table 3. Potential biomarkers of SCI severity identified by quantitative LC-MS/MS analysis of CSF from rats following experimental SCI.

	Protein ID	Protein Description	Protein Symbol	Moderate/sham		Severe/sham		Gene Ontology
				AVG ratios	SEM	AVG ratios	SEM
1	IPI00188541	Inter-alpha-inhibitor H4 heavy chain	Itih4	4.5	0.41	1.8	0.33	hyaluronan metabolic process; acute phase response
2	IPI00476458	Glutathione peroxidase 3	Gpx3	4.2	0.30	1.9	0.27	glutathione metabolic process; hydrogen peroxide catabolic process; oxidation reduction; protein homotetramerization; response to oxidative stress
3	IPI00326140	Pregnancy zone protein	Pzp	3.9	0.41	2.1	0.36	pregnancy
4	IPI00360930	Carbonic anhydrase 1	Car1	2.4	0.21	0.4	0.12	one-carbon metabolic process
5	IPI00207146	Zero beta-1 globin	MGC72973	6.1	0.78	1.0	0.31	oxygen transport
6	IPI00191715	Alpha-1-acid glycoprotein	Orm1	2.1	0.18	0.9	0.21	acute-phase response; regulation of immune system process

Proteins consistently changed across three LC-MS/MS runs.

Selection of potential biomarkers of SCI severity was based on more than two-fold difference in the average ratio between the two injury models. AVG – average; SEM – standard error of the mean.