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. 2011 Apr 29;6(4):e19353. doi: 10.1371/journal.pone.0019353

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Yang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The heat map denotes the average absolute value of the normalized sensitivity coefficients of four GAL mRNA across 1000 minutes. The parameters , , , , , , , , , , and are smaller than 0.25, while the others are larger than 1. This implies the reaction terms associated with insensitive parameters can be omitted no matter which mRNA is chosen as the control target. One can conclude not only that the control model targeting GAL1 mRNA need not include the terms associated with the above parameters, but also that control strategies targeting all four GAL mRNAs can suppress the same terms. The reduced model can thus be used for the control design targeting any of the four GAL mRNAs.

Inline graphic — The heat map denotes the average absolute value of the normalized sensitivity coefficients of four GAL mRNA across 1000 minutes. The parameters , , , , , , , , , , and are smaller than 0.25, while the others are larger than 1. This implies the reaction terms associated with insensitive parameters can be omitted no matter which mRNA is chosen as the control target. One can conclude not only that the control model targeting GAL1 mRNA need not include the terms associated with the above parameters, but also that control strategies targeting all four GAL mRNAs can suppress the same terms. The reduced model can thus be used for the control design targeting any of the four GAL mRNAs.